Data gaps limit success of national indicators
نویسندگان
چکیده
منابع مشابه
Data gaps limit the translational potential of preclinical research.
The absence of mouse pharmacokinetic reference data hinders translation. An analysis of recent literature highlights a systematic lack of discussion regarding rationale for the selection of dosing paradigms in preclinical studies, and in particular for neuroscience studies in which the lack of brain penetration can limit target-organ exposure. We propose solutions to improve study design.
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on A ril 2, 2017 ht://stm .scencem agorg/ D ow nladed from Despite widespread use of pharmacological agents in mouse models of human disease, the literature lacks comprehensive pharmacokinetic profiles for such studies. Coupled with a paucity of suitable data are shortcomings in the training of experimental biologists in the application of pharmacometric principles to experimental study design....
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ژورنال
عنوان ژورنال: Environmental Science & Technology
سال: 2003
ISSN: 0013-936X,1520-5851
DOI: 10.1021/es0326219